MolNFT v1 · #9377 · protein

A novel dimer configuration revealed by the crystal structure at 2.4 ångströms resolution of human interleukin- 5

1HUL · Interleukin-5: “A novel dimer configuration revealed by the crystal structure at 2.4 ångströms resolution of human…”. X-ray diffraction, 1 pocket (best druggability 0.40). MolNFT v1 #9377 on GenesisL1: 3D structure, binding sites…

PDB: 1HUL
Type: protein
Length: 216 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Interleukin-5
UniProt: P05113
Pockets: 1 · best druggability 0.40

Structure

x-ray diffraction · 1 distinct chain · 66% helix, 7% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Interleukin-5	protein	108	66% helix, 7% strand	P05113

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	66	0.40	0.80	12	empty

Interfaces

1 interface between chains.

A–B · 3424 Å² buried · 27 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

1HUL · A novel dimer configuration revealed by the crystal structure at 2.4 ångströms resolution… · the same entry in another collection · chain B against B, TM-score 1.00
P05113 · AlphaFold monomer V2.0 prediction for interleukin-5 (P05113) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P05113
Elsewhere: RCSB PDB 1HUL · PDBe 1HUL · UniProt P05113

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