Crystal structure of Fc-fragment of human IGG2 antibody (primitive crystal form)

Structure

x-ray diffraction · 2 distinct chains · 12% helix, 47% strand (DSSP).

Ligands and binding sites

• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 4 copies · chains A
• MAN · alpha-D-mannopyranose · sugar · 2 copies · chains A
• BMA · beta-D-mannopyranose · sugar · chains A
• FUC · alpha-L-fucopyranose · sugar · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 1186 Ų buried · 7 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide, 1 glycan (disulfide, N-glycosylation).

Compared structures

• 4HAF · Crystal structure of fc-fragment of human IgG2 antibody (primitive crystal form) · the same entry in another collection · chain A against A, TM-score 1.00
• P01859 · AlphaFold monomer V2.0 prediction for immunoglobulin heavy constant gamma 2 (P01859) · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P01859
• Elsewhere: RCSB PDB 4HAF · PDBe 4HAF · UniProt P01859