MolNFT v1 · #93554 · protein

HSC70 nbd with mg

4H5V · Heat shock cognate 71 kda protein: “HSC70 nbd with mg”. X-ray diffraction, 3 ligands (MG, SO4, CL), 2 pockets (best druggability 0.74). MolNFT v1 #93554 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4H5V
Type: protein
Length: 382 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Heat shock cognate 71 kda protein
UniProt: P11142
Ligands: MG, SO4, CL
Pockets: 2 · best druggability 0.74

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Heat shock cognate 71 kda protein	protein	382	40% helix, 29% strand	P11142

Ligands and binding sites

MG · Magnesium ion · metal · chains A
SO4 · Sulfate ion · ion · 3 copies · chains A
CL · Chloride ion · ion · chains A
GOL · Glycerol · additive · 4 copies · chains A
ACT · Acetate ion · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	441	0.74	0.84	55	SO4, MG, CL, GOL
2	311	0.57	0.76	30	empty

Compared structures

4H5V · HSC70 NBD with Mg · the same entry in another collection · chain A against A, TM-score 1.00
P11142 · AlphaFold monomer V2.0 prediction for heat shock cognate 71 kda protein (P11142) · a predicted model of the same protein · chain A against A, TM-score 0.87

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P11142
Elsewhere: RCSB PDB 4H5V · PDBe 4H5V · UniProt P11142

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