MolNFT v1 · #93459 · protein

Crystal structure of the tyrosine phosphatase shp-2 with Q506P mutation

4H34 · Tyrosine-protein phosphatase non-receptor type 11: “Crystal structure of the tyrosine phosphatase shp-2 with Q506P mutation”. X-ray diffraction, 4 pockets (best druggability 0.64). MolNFT v1 #93459 on GenesisL1: 3D structure…

PDB: 4H34
Type: protein
Length: 486 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tyrosine-protein phosphatase non-receptor type 11
EC: 3.1.3.48
UniProt: Q06124
Pockets: 4 · best druggability 0.64

Structure

x-ray diffraction · 1 distinct chain · 30% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48)	protein	486	30% helix, 24% strand	Q06124

Ligands and binding sites

EDO · 1,2-ethanediol · additive · 6 copies · chains A
GOL · Glycerol · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	461	0.64	0.77	43	empty
2	227	0.53	0.77	49	EDO
3	80	0.43	0.80	18	empty
4	56	0.27	0.74	15	empty

Compared structures

4H34 · Crystal structure of the tyrosine phosphatase SHP-2 with Q506P mutation · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q06124
Elsewhere: RCSB PDB 4H34 · PDBe 4H34 · UniProt Q06124

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