MolNFT v1 · #93351 · protein
Crystal structure of the dh-pH-pH domain of FARP2
4GZU · Ferm, rhogef and pleckstrin domain-containing protein 2: “Crystal structure of the dh-pH-pH domain of FARP2”. X-ray diffraction, 13 pockets (best druggability 0.76). MolNFT v1 #93351 on GenesisL1: 3D structure, binding sites and…
- PDB
- 4GZU
- Type
- protein
- Length
- 854 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ferm, rhogef and pleckstrin domain-containing protein 2
- UniProt
- Q91VS8
- Pockets
- 13 · best druggability 0.76
Structure
x-ray diffraction · 2 distinct chains · 47% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ferm, rhogef and pleckstrin domain-containing protein 2 | protein | 436 | 47% helix, 21% strand | Q91VS8 |
| B | Ferm, rhogef and pleckstrin domain-containing protein 2 | protein | 418 | 47% helix, 20% strand | Q91VS8 |
Pockets
13 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 136 | 0.76 | 0.94 | 25 | empty |
| 2 | 58 | 0.70 | 0.98 | 16 | empty |
| 3 | 426 | 0.70 | 0.81 | 68 | empty |
| 4 | 82 | 0.65 | 0.92 | 22 | empty |
| 5 | 153 | 0.58 | 0.82 | 26 | empty |
Interfaces
1 interface between chains.
- A–B · 626 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q91VS8
- Elsewhere: RCSB PDB 4GZU · PDBe 4GZU · UniProt Q91VS8
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