MolNFT v1 · #93285 · protein

Crystal structure of anti-influenza virus antibody 1F1

4GXV · Antibody 1F1, heavy chain: “Crystal structure of anti-influenza virus antibody 1F1”. X-ray diffraction, 9 pockets (best druggability 0.77). MolNFT v1 #93285 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4GXV
Type: protein
Length: 884 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Antibody 1F1, heavy chain; Antibody 1F1, light chain
Pockets: 9 · best druggability 0.77

Structure

x-ray diffraction · 2 distinct chains · 9% helix, 50% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
H, I	Antibody 1F1, heavy chain	protein	228	11% helix, 50% strand	—
L, M	Antibody 1F1, light chain	protein	214	7% helix, 51% strand	—

Pockets

9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	901	0.77	0.80	87	empty
2	575	0.60	0.73	58	empty
3	403	0.56	0.74	43	empty
4	106	0.40	0.76	24	empty
5	157	0.40	0.73	27	empty

Interfaces

5 interfaces between chains.

H–L · 1935 Å² buried · 19 hydrogen bonds · protein-protein
I–M · 1926 Å² buried · 11 hydrogen bonds · protein-protein
H–I · 319 Å² buried · 2 hydrogen bonds · protein-protein
L–I · 13 Å² buried · 0 hydrogen bonds · protein-protein
H–M · 13 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 8 disulfide, 4 modified (disulfide, cyclization).

Compared structures

4GXV · Crystal structure of anti-influenza virus antibody 1F1 · the same entry in another collection · chain H against H, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 4GXV · PDBe 4GXV

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