Research workbench
Crystal structure of anti-influenza virus antibody 1F1
Analyse Crystal structure of anti-influenza virus antibody 1F1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4GXV
- Type
- protein
- Length
- 884 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Antibody 1F1, heavy chain; Antibody 1F1, light chain
- Pockets
- 9 · best druggability 0.77
Structure
x-ray diffraction · 2 distinct chains · 9% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H, I | Antibody 1F1, heavy chain | protein | 228 | 11% helix, 50% strand | — |
| L, M | Antibody 1F1, light chain | protein | 214 | 7% helix, 51% strand | — |
Pockets
9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 901 | 0.77 | 0.80 | 87 | empty |
| 2 | 575 | 0.60 | 0.73 | 58 | empty |
| 3 | 403 | 0.56 | 0.74 | 43 | empty |
| 4 | 106 | 0.40 | 0.76 | 24 | empty |
| 5 | 157 | 0.40 | 0.73 | 27 | empty |
Interfaces
5 interfaces between chains.
- H–L · 1935 Ų buried · 19 hydrogen bonds · protein-protein
- I–M · 1926 Ų buried · 11 hydrogen bonds · protein-protein
- H–I · 319 Ų buried · 2 hydrogen bonds · protein-protein
- L–I · 13 Ų buried · 0 hydrogen bonds · protein-protein
- H–M · 13 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide, 4 modified (disulfide, cyclization).
Compared structures
- 4GXV · Crystal structure of anti-influenza virus antibody 1F1 · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 4GXV · PDBe 4GXV
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