MolNFT v1 · #93156 · protein
Structure of full-length drosophila cryptochrome
4GU5 · Cryptochrome-1: “Structure of full-length drosophila cryptochrome”. X-ray diffraction, 2 ligands (FAD, MG), 9 pockets (best druggability 0.85). MolNFT v1 #93156 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4GU5
- Type
- protein
- Length
- 1,075 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cryptochrome-1
- UniProt
- O77059
- Ligands
- FAD, MG
- Pockets
- 9 · best druggability 0.85
Structure
x-ray diffraction · 2 distinct chains · 50% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cryptochrome-1 | protein | 537 | 50% helix, 7% strand | O77059 |
| B | Cryptochrome-1 | protein | 538 | 50% helix, 7% strand | O77059 |
Ligands and binding sites
- FAD · Flavin-adenine dinucleotide · ligand · 2 copies · chains A, B
- MG · Magnesium ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 872 | 0.85 | 0.86 | 55 | MG, FAD |
| 2 | 810 | 0.84 | 0.86 | 53 | MG, FAD |
| 3 | 739 | 0.77 | 0.81 | 52 | empty |
| 4 | 662 | 0.75 | 0.81 | 77 | empty |
| 5 | 104 | 0.57 | 0.85 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 940 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O77059
- Elsewhere: RCSB PDB 4GU5 · PDBe 4GU5 · UniProt O77059
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.