MolNFT v1 · #93103 · protein

Crystal structure of ATG7 ntd K14A F16A D18A mutant

4GSJ · Ubiquitin-like modifier-activating enzyme ATG7: “Crystal structure of ATG7 ntd K14A F16A D18A mutant”. X-ray diffraction, 4 pockets (best druggability 0.43). MolNFT v1 #93103 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 4GSJ
Type: protein
Length: 288 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ubiquitin-like modifier-activating enzyme ATG7
UniProt: P38862
Pockets: 4 · best druggability 0.43

Structure

x-ray diffraction · 1 distinct chain · 26% helix, 35% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ubiquitin-like modifier-activating enzyme ATG7	protein	288	26% helix, 35% strand	P38862

Ligands and binding sites

IPA · Isopropyl alcohol · additive · 6 copies · chains A
CIT · Citric acid · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	126	0.43	0.76	26	empty
2	73	0.39	0.78	18	empty
3	79	0.33	0.75	20	empty
4	55	0.27	0.74	10	empty

Compared structures

4GSJ · Crystal structure of Atg7 NTD K14A F16A D18A mutant · the same entry in another collection · chain A against A, TM-score 1.00
P38862 · AlphaFold monomer V2.0 prediction for ubiquitin-like modifier- activating enzyme ATG7… · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P38862
Elsewhere: RCSB PDB 4GSJ · PDBe 4GSJ · UniProt P38862

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