MolNFT v1 · #93018 · protein
S. pombe NUP120-NUP37 complex
4GQ2 · Nucleoporin NUP120: “S. pombe NUP120-NUP37 complex”. X-ray diffraction, 18 pockets (best druggability 0.82). MolNFT v1 #93018 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4GQ2
- Type
- protein
- Length
- 1,275 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nucleoporin NUP120; NUP37
- UniProt
- O43044, O36030
- Pockets
- 18 · best druggability 0.82
Structure
x-ray diffraction · 2 distinct chains · 29% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| M | Nucleoporin NUP120 | protein | 904 | 39% helix, 23% strand | O43044 |
| P | NUP37 | protein | 371 | 4% helix, 50% strand | O36030 |
Pockets
18 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 339 | 0.82 | 0.92 | 59 | empty |
| 2 | 1097 | 0.81 | 0.83 | 80 | empty |
| 3 | 145 | 0.76 | 0.94 | 27 | empty |
| 4 | 219 | 0.71 | 0.87 | 33 | empty |
| 5 | 96 | 0.68 | 0.92 | 23 | empty |
Interfaces
1 interface between chains.
- M–P · 2273 Ų buried · 23 hydrogen bonds · protein-protein
Compared structures
- 4GQ2 · S. pombe Nup120-Nup37 complex · the same entry in another collection · chain M against M, TM-score 1.00
- O43044 · AlphaFold monomer V2.0 prediction for nucleoporin NUP120 (O43044) · a predicted model of the same protein · chain M against A, TM-score 0.97
- O36030 · AlphaFold monomer V2.0 prediction for uncharacterized wd repeat- containing protein… · a predicted model of the same protein · chain P against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O43044
- Every structure of UniProt O36030
- Elsewhere: RCSB PDB 4GQ2 · PDBe 4GQ2 · UniProt O43044 · UniProt O36030
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