MolNFT v1 · #9293 · protein

Crystal structure of human chorionic gonadotropin

1HRP: “Crystal structure of human chorionic gonadotropin”. X-ray diffraction, 1 ligand (NAG), 2 pockets (best druggability 0.57). MolNFT v1 #9293 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1HRP
Type: protein
Length: 196 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Human chorionic gonadotropin
UniProt: P01215, P01233
Ligands: NAG
Pockets: 2 · best druggability 0.57

Structure

x-ray diffraction · 2 distinct chains · 2% helix, 52% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Human chorionic gonadotropin	protein	86	5% helix, 59% strand	P01215
B	Human chorionic gonadotropin	protein	110	0% helix, 46% strand	P01233

Ligands and binding sites

NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 6 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	204	0.57	0.79	33	empty
2	144	0.42	0.75	22	empty

Interfaces

1 interface between chains.

A–B · 2056 Å² buried · 38 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 11 disulfide, 4 glycan (disulfide, N-glycosylation).

Compared structures

1HRP · Crystal structure of human chorionic gonadotropin · the same entry in another collection · chain A against A, TM-score 1.00
P01215 · AlphaFold monomer V2.0 prediction for glycoprotein hormones alpha chain (P01215) · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01215
Every structure of UniProt P01233
Elsewhere: RCSB PDB 1HRP · PDBe 1HRP · UniProt P01215 · UniProt P01233

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