MolNFT v1 · #92918 · protein

Crystal structure of oxa-45, a class D beta-lactamase with extended spectrum activity

4GN2 · Oxacillinase: “Crystal structure of oxa-45, a class D beta-lactamase with extended spectrum activity”. X-ray diffraction, 2 pockets (best druggability 0.42). MolNFT v1 #92918 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 4GN2
Type: protein
Length: 240 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Oxacillinase
EC: 3.5.2.6
UniProt: Q7WZC7
Pockets: 2 · best druggability 0.42

Structure

x-ray diffraction · 1 distinct chain · 39% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Oxacillinase (EC 3.5.2.6)	protein	240	39% helix, 25% strand	Q7WZC7

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	137	0.42	0.75	24	empty
2	57	0.23	0.71	24	empty

Modifications

Observed in the structure: 1 disulfide, 1 modified (disulfide, carboxylation).

Compared structures

4GN2 · Crystal Structure of OXA-45, a Class D beta-lactamase with extended spectrum activity · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q7WZC7
Elsewhere: RCSB PDB 4GN2 · PDBe 4GN2 · UniProt Q7WZC7

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