MolNFT v1 · #92803 · protein
Streptavidin-K121H
4GJS: “Streptavidin-K121H”. X-ray diffraction, 2 ligands (0OD, RH), 2 pockets (best druggability 0.46). MolNFT v1 #92803 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4GJS
- Type
- protein
- Length
- 244 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Streptavidin
- UniProt
- P22629
- Ligands
- 0OD, RH
- Pockets
- 2 · best druggability 0.46
Structure
x-ray diffraction · 1 distinct chain · 8% helix, 54% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Streptavidin | protein | 122 | 8% helix, 54% strand | P22629 |
Ligands and binding sites
- 0OD · trichloro{(1,2,3,4,5-eta)-1,2,3,4-tetramethyl-5-[2-({5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}amino)ethyl]cyclopentadienyl}rhodium(1+) · ligand · 2 copies · chains A, B
- RH · Rhodium · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 128 | 0.46 | 0.78 | 27 | 0OD |
| 2 | 90 | 0.46 | 0.80 | 17 | 0OD |
Interfaces
1 interface between chains.
- A–B · 217 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 4GJS · Streptavidin-K121H · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P22629
- Elsewhere: RCSB PDB 4GJS · PDBe 4GJS · UniProt P22629
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