MolNFT v1 · #92693 · protein

Structural analysis of human CDC20 supports multi-site degron recognition by APC/C

4GGA · Cell division cycle protein 20 homolog: “Structural analysis of human CDC20 supports multi-site degron recognition by APC/C”. X-ray diffraction, 2 pockets (best druggability 0.73). MolNFT v1 #92693 on GenesisL1: 3D structure…

PDB: 4GGA
Type: protein
Length: 314 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cell division cycle protein 20 homolog
UniProt: Q12834
Pockets: 2 · best druggability 0.73

Structure

x-ray diffraction · 1 distinct chain · 0% helix, 50% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cell division cycle protein 20 homolog	protein	314	0% helix, 50% strand	Q12834

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	590	0.73	0.81	47	empty
2	52	0.39	0.80	11	empty

Compared structures

4GGA · Structural Analysis of Human Cdc20 Supports Multi-site Degron Recognition by APC/C · the same entry in another collection · chain A against A, TM-score 1.00
Q12834 · AlphaFold monomer V2.0 prediction for cell division cycle protein 20 homolog (Q12834) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q12834
Elsewhere: RCSB PDB 4GGA · PDBe 4GGA · UniProt Q12834

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