MolNFT v1 · #9266 · protein

Structure of apoptosis-linked protein alg-2

1HQV · Programmed cell death protein 6: “Structure of apoptosis-linked protein alg-2”. X-ray diffraction, 1 ligand (CA), 2 pockets (best druggability 0.42). MolNFT v1 #9266 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1HQV
Type: protein
Length: 178 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Programmed cell death protein 6
UniProt: P12815
Ligands: CA
Pockets: 2 · best druggability 0.42

Structure

x-ray diffraction · 1 distinct chain · 57% helix, 3% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Programmed cell death protein 6	protein	178	57% helix, 3% strand	P12815

Ligands and binding sites

CA · Calcium ion · metal · 4 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	142	0.42	0.74	24	empty
2	60	0.34	0.77	14	empty

Compared structures

1HQV · Structure of apoptosis-linked protein alg-2 · the same entry in another collection · chain A against A, TM-score 1.00
P12815 · AlphaFold monomer V2.0 prediction for programmed cell death protein 6 (P12815) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P12815
Elsewhere: RCSB PDB 1HQV · PDBe 1HQV · UniProt P12815

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