MolNFT v1 · #92422 · protein
The structure of the PLK4 cryptic polo box reveals two tandem polo boxes required for centriole duplication
4G7N · SERINE/THREONINE-protein kinase PLK4: “The structure of the PLK4 cryptic polo box reveals two tandem polo boxes required for centriole duplication”. X-ray diffraction, 1 ligand (SO4), 3 pockets (best druggability 0.61). MolNFT v1…
- PDB
- 4G7N
- Type
- protein
- Length
- 433 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SERINE/THREONINE-protein kinase PLK4
- EC
- 2.7.11.21
- UniProt
- O97143
- Ligands
- SO4
- Pockets
- 3 · best druggability 0.61
Structure
x-ray diffraction · 2 distinct chains · 21% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SERINE/THREONINE-protein kinase PLK4 (EC 2.7.11.21) | protein | 218 | 21% helix, 32% strand | O97143 |
| B | SERINE/THREONINE-protein kinase PLK4 (EC 2.7.11.21) | protein | 215 | 21% helix, 32% strand | O97143 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 6 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 327 | 0.61 | 0.78 | 49 | empty |
| 2 | 235 | 0.49 | 0.74 | 31 | empty |
| 3 | 80 | 0.32 | 0.74 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 1345 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 4G7N · The Structure of the Plk4 Cryptic Polo Box Reveals Two Tandem Polo Boxes Required for… · the same entry in another collection · chain A against A, TM-score 1.00
- O97143 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase PLK4 (O97143) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O97143
- Elsewhere: RCSB PDB 4G7N · PDBe 4G7N · UniProt O97143
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