Research workbench
The structure of the PLK4 cryptic polo box reveals two tandem polo boxes required for centriole duplication
Analyse The structure of the PLK4 cryptic polo box reveals two tandem polo boxes… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4G7N
- Type
- protein
- Length
- 433 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SERINE/THREONINE-protein kinase PLK4
- EC
- 2.7.11.21
- UniProt
- O97143
- Ligands
- SO4
- Pockets
- 3 · best druggability 0.61
Structure
x-ray diffraction · 2 distinct chains · 21% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SERINE/THREONINE-protein kinase PLK4 (EC 2.7.11.21) | protein | 218 | 21% helix, 32% strand | O97143 |
| B | SERINE/THREONINE-protein kinase PLK4 (EC 2.7.11.21) | protein | 215 | 21% helix, 32% strand | O97143 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 6 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 327 | 0.61 | 0.78 | 49 | empty |
| 2 | 235 | 0.49 | 0.74 | 31 | empty |
| 3 | 80 | 0.32 | 0.74 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 1345 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 4G7N · The Structure of the Plk4 Cryptic Polo Box Reveals Two Tandem Polo Boxes Required for… · the same entry in another collection · chain A against A, TM-score 1.00
- O97143 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase PLK4 (O97143) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O97143
- Elsewhere: RCSB PDB 4G7N · PDBe 4G7N · UniProt O97143
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