MolNFT v1 · #92013 · protein

Crystal structure of the urokinase

4FUG · Urokinase-type plasminogen activator: “Crystal structure of the urokinase”. X-ray diffraction, 2 ligands (9UP, SO4), 2 pockets (best druggability 0.46). MolNFT v1 #92013 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4FUG
Type: protein
Length: 246 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Urokinase-type plasminogen activator
EC: 3.4.21.73
UniProt: P00749
Ligands: 9UP, SO4
Pockets: 2 · best druggability 0.46

Structure

x-ray diffraction · 1 distinct chain · 11% helix, 39% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Urokinase-type plasminogen activator (EC 3.4.21.73)	protein	246	11% helix, 39% strand	P00749

Ligands and binding sites

9UP · methyl (7-carbamimidoylnaphthalen-1-yl)carbamate · ligand · chains A
SO4 · Sulfate ion · ion · 4 copies · chains A
GOL · Glycerol · additive · 2 copies · chains A
ACT · Acetate ion · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	165	0.46	0.76	34	9UP, SO4
2	69	0.37	0.78	15	empty

Modifications

Observed in the structure: 5 disulfide (disulfide).

Compared structures

4FUG · Crystal Structure of the Urokinase · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00749
Elsewhere: RCSB PDB 4FUG · PDBe 4FUG · UniProt P00749

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