MolNFT v1 · #92009 · protein

Crystal structure of the urokinase

4FUC · Urokinase-type plasminogen activator: “Crystal structure of the urokinase”. X-ray diffraction, 2 ligands (239, SO4), 2 pockets (best druggability 0.48). MolNFT v1 #92009 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4FUC
Type: protein
Length: 246 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Urokinase-type plasminogen activator
EC: 3.4.21.73
UniProt: P00749
Ligands: 239, SO4
Pockets: 2 · best druggability 0.48

Structure

x-ray diffraction · 1 distinct chain · 11% helix, 40% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Urokinase-type plasminogen activator (EC 3.4.21.73)	protein	246	11% helix, 40% strand	P00749

Ligands and binding sites

239 · 6-[(Z)-amino(imino)methyl]-N-[4-(aminomethyl)phenyl]-2-naphthamide · ligand · chains A
SO4 · Sulfate ion · ion · 4 copies · chains A
GOL · Glycerol · additive · 8 copies · chains A
SIN · Succinic acid · additive · chains A
ACT · Acetate ion · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	181	0.48	0.76	36	239, SIN
2	75	0.35	0.76	17	empty

Modifications

Observed in the structure: 5 disulfide (disulfide).

Compared structures

4FUC · Crystal Structure of the Urokinase · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00749
Elsewhere: RCSB PDB 4FUC · PDBe 4FUC · UniProt P00749

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