MolNFT v1 · #91904 · protein

TRNA-guanine transglycosylase cocrystallized with pyridyl-alkine- substituted lin-benzoguanine ligand

4FR6 · Queuine tRNA-ribosyltransferase: “TRNA-guanine transglycosylase cocrystallized with pyridyl-alkine- substituted lin-benzoguanine ligand”. X-ray diffraction, 2 ligands (0V3, ZN), 3 pockets (best druggability 0.61). MolNFT v1 #91904…

PDB: 4FR6
Type: protein
Length: 342 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Queuine tRNA-ribosyltransferase
EC: 2.4.2.29
UniProt: P28720
Ligands: 0V3, ZN
Pockets: 3 · best druggability 0.61

Structure

x-ray diffraction · 1 distinct chain · 48% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Queuine tRNA-ribosyltransferase (EC 2.4.2.29)	protein	342	48% helix, 15% strand	P28720

Ligands and binding sites

0V3 · 6-amino-2-(methylamino)-4-[2-({[trans-4-(pyridin-3-ylethynyl)cyclohexyl]methyl}amino)ethyl]-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one · ligand · chains A
ZN · Zinc ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	222	0.61	0.81	36	0V3
2	71	0.35	0.76	19	empty
3	53	0.28	0.75	12	empty

Compared structures

4FR6 · tRNA-Guanine Transglycosylase cocrystallized with pyridyl-alkine-substituted… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P28720
Elsewhere: RCSB PDB 4FR6 · PDBe 4FR6 · UniProt P28720

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.