MolNFT v1 · #91867 · protein

Crystal structure of TRANSPORTIN/FUS-nls

4FQ3 · Transportin-1: “Crystal structure of TRANSPORTIN/FUS-nls”. X-ray diffraction, 7 pockets (best druggability 0.55). MolNFT v1 #91867 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4FQ3
Type: protein
Length: 853 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transportin-1; Fusion (involved in T(12
UniProt: Q92973, Q8TBR3
Pockets: 7 · best druggability 0.55

Structure

x-ray diffraction · 2 distinct chains · 72% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Transportin-1	protein	834	73% helix, 0% strand	Q92973
B	Fusion (involved in T(12	protein	19	37% helix, 0% strand	Q8TBR3

Pockets

7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	202	0.55	0.79	20	empty
2	180	0.45	0.74	23	empty
3	52	0.35	0.79	15	empty
4	80	0.34	0.76	15	empty
5	84	0.33	0.74	20	empty

Interfaces

1 interface between chains.

A–B · 1323 Å² buried · 25 hydrogen bonds · protein-protein

Compared structures

4FQ3 · Crystal structure of transportin/FUS-NLS · the same entry in another collection · chain A against A, TM-score 1.00
Q92973 · AlphaFold monomer V2.0 prediction for transportin-1 (Q92973) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q92973
Every structure of UniProt Q8TBR3
Elsewhere: RCSB PDB 4FQ3 · PDBe 4FQ3 · UniProt Q92973 · UniProt Q8TBR3

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