MolNFT v1 · #91796 · protein
Crystal structure of the apo F1174L anaplastic lymphoma kinase catalytic domain
4FNW · ALK tyrosine kinase receptor: “Crystal structure of the apo F1174L anaplastic lymphoma kinase catalytic domain”. X-ray diffraction, 4 pockets (best druggability 0.50). MolNFT v1 #91796 on GenesisL1: 3D structure, binding sites and…
- PDB
- 4FNW
- Type
- protein
- Length
- 304 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ALK tyrosine kinase receptor
- EC
- 2.7.10.1
- UniProt
- Q9UM73
- Pockets
- 4 · best druggability 0.50
Structure
x-ray diffraction · 1 distinct chain · 42% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | ALK tyrosine kinase receptor (EC 2.7.10.1) | protein | 304 | 42% helix, 15% strand | Q9UM73 |
Ligands and binding sites
- GOL · Glycerol · additive · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 174 | 0.50 | 0.77 | 23 | empty |
| 2 | 56 | 0.35 | 0.78 | 13 | GOL |
| 3 | 65 | 0.32 | 0.75 | 14 | empty |
| 4 | 76 | 0.30 | 0.74 | 21 | empty |
Compared structures
- 4FNW · Crystal structure of the apo F1174L anaplastic lymphoma kinase catalytic domain · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UM73 · AlphaFold monomer V2.0 prediction for ALK tyrosine kinase receptor (Q9UM73) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UM73
- Elsewhere: RCSB PDB 4FNW · PDBe 4FNW · UniProt Q9UM73
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