MolNFT v1 · #91629 · protein

Crystal structure of GLFT2 complexed with udp

4FIY · Udp-galactofuranosyl transferase GLFT2: “Crystal structure of GLFT2 complexed with udp”. X-ray diffraction, 2 ligands (UDP, MN), 11 pockets (best druggability 0.79). MolNFT v1 #91629 on GenesisL1: 3D structure, binding sites and…

PDB: 4FIY
Type: protein
Length: 1,256 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Udp-galactofuranosyl transferase GLFT2
EC: 2.4.1.-
UniProt: O53585
Ligands: UDP, MN
Pockets: 11 · best druggability 0.79

Structure

x-ray diffraction · 1 distinct chain · 36% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Udp-galactofuranosyl transferase GLFT2 (EC 2.4.1.-)	protein	628	36% helix, 24% strand	O53585

Ligands and binding sites

UDP · Uridine-5'-diphosphate · ligand · 2 copies · chains A, B
MN · Manganese (II) ion · metal · 2 copies · chains A, B
GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

11 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1048	0.79	0.81	77	UDP, MN
2	1040	0.78	0.80	77	UDP, MN
3	815	0.72	0.77	62	empty
4	313	0.57	0.76	50	empty
5	178	0.52	0.78	32	empty

Interfaces

1 interface between chains.

A–B · 263 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

4FIY · Crystal Structure of GlfT2 Complexed with UDP · the same entry in another collection · chain A against A, TM-score 1.00
O53585 · AlphaFold monomer V2.0 prediction for galactofuranosyltransferase GLFT2 (O53585) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O53585
Elsewhere: RCSB PDB 4FIY · PDBe 4FIY · UniProt O53585

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