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MolNFT v1 · #91588 · protein

Crystal structures of the CID1 poly (U) polymerase reveal the mechanism for UTP selectivity - cautp bound

4FHP · POLY(A) RNA polymerase protein CID1: “Crystal structures of the CID1 poly (U) polymerase reveal the mechanism for UTP selectivity - cautp bound”. X-ray diffraction, 2 ligands (UTP, CA), 2 pockets (best druggability 0.69). MolNFT v1…

PDB
4FHP
Type
protein
Length
323 residues
Chains
1
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
POLY(A) RNA polymerase protein CID1
EC
2.7.7.-
UniProt
O13833
Ligands
UTP, CA
Pockets
2 · best druggability 0.69

Structure

x-ray diffraction · 1 distinct chain · 44% helix, 14% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
APOLY(A) RNA polymerase protein CID1 (EC 2.7.7.-)protein32344% helix, 14% strandO13833

Ligands and binding sites

  • UTP · Uridine 5'-triphosphate · ligand · chains A
  • CA · Calcium ion · metal · chains A
  • GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
17820.690.7656UTP, CA
2660.320.7513empty

Compared structures

  • 4FHP · Crystal structures of the Cid1 poly (U) polymerase reveal the mechanism for UTP… · the same entry in another collection · chain A against A, TM-score 1.00
  • O13833 · AlphaFold monomer V2.0 prediction for terminal uridylyltransferase CID1 (O13833) · a predicted model of the same protein · chain A against A, TM-score 0.99

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