MolNFT v1 · #91585 · protein
NUP37-NUP120(AA1-961) complex from schizosaccharomyces pombe
4FHM · Nucleoporin NUP37: “NUP37-NUP120(AA1-961) complex from schizosaccharomyces pombe”. X-ray diffraction, 20 pockets (best druggability 0.87). MolNFT v1 #91585 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4FHM
- Type
- protein
- Length
- 1,274 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nucleoporin NUP37; Nucleoporin NUP120
- UniProt
- O36030, O43044
- Pockets
- 20 · best druggability 0.87
Structure
x-ray diffraction · 2 distinct chains · 27% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nucleoporin NUP37 | protein | 354 | 3% helix, 53% strand | O36030 |
| B | Nucleoporin NUP120 | protein | 920 | 37% helix, 17% strand | O43044 |
Pockets
20 pockets found on a 1 Å grid, 18 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1135 | 0.87 | 0.88 | 115 | empty |
| 2 | 1043 | 0.85 | 0.85 | 81 | empty |
| 3 | 738 | 0.84 | 0.87 | 75 | empty |
| 4 | 985 | 0.81 | 0.82 | 92 | empty |
| 5 | 549 | 0.80 | 0.86 | 57 | empty |
Interfaces
1 interface between chains.
- A–B · 2682 Ų buried · 29 hydrogen bonds · protein-protein
Compared structures
- 4FHM · Nup37-Nup120(aa1-961) complex from Schizosaccharomyces pombe · the same entry in another collection · chain A against A, TM-score 1.00
- O43044 · AlphaFold monomer V2.0 prediction for nucleoporin NUP120 (O43044) · a predicted model of the same protein · chain B against A, TM-score 0.96
- O36030 · AlphaFold monomer V2.0 prediction for uncharacterized wd repeat- containing protein… · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O36030
- Every structure of UniProt O43044
- Elsewhere: RCSB PDB 4FHM · PDBe 4FHM · UniProt O36030 · UniProt O43044
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