MolNFT v1 · #91532 · protein
Crystal structure analysis of the human insulin
4FG3: “Crystal structure analysis of the human insulin”. X-ray diffraction, 2 ligands (ZN, CL). MolNFT v1 #91532 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4FG3
- Type
- protein
- Length
- 102 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin
- UniProt
- P01308
- Ligands
- ZN, CL
Structure
x-ray diffraction · 2 distinct chains · 55% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Insulin | protein | 21 | 67% helix, 10% strand | P01308 |
| B, D | Insulin | protein | 30 | 47% helix, 13% strand | P01308 |
Ligands and binding sites
- ZN · Zinc ion · metal · 2 copies · chains B, D
- CL · Chloride ion · ion · 2 copies · chains D
- GOL · Glycerol · additive · chains D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
5 interfaces between chains.
- A–B · 931 Ų buried · 12 hydrogen bonds · protein-protein
- C–D · 878 Ų buried · 10 hydrogen bonds · protein-protein
- B–D · 656 Ų buried · 11 hydrogen bonds · protein-protein
- A–D · 76 Ų buried · 1 hydrogen bond · protein-protein
- B–C · 42 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 4FG3 · Crystal Structure Analysis of the Human Insulin · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01308
- Elsewhere: RCSB PDB 4FG3 · PDBe 4FG3 · UniProt P01308
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