MolNFT v1 · #91448 · protein

Crystal structure of caspase-7

4FDL: “Crystal structure of caspase-7”. X-ray diffraction, 1 pocket (best druggability 0.75). MolNFT v1 #91448 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4FDL
Type: protein
Length: 471 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Caspase-7
EC: 3.4.22.60
UniProt: P55210
Pockets: 1 · best druggability 0.75

Structure

x-ray diffraction · 2 distinct chains · 30% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Caspase-7 (EC 3.4.22.60)	protein	232	30% helix, 27% strand	P55210
B	Caspase-7 (EC 3.4.22.60)	protein	239	29% helix, 25% strand	P55210

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	430	0.75	0.84	41	empty

Interfaces

1 interface between chains.

A–B · 2239 Å² buried · 32 hydrogen bonds · protein-protein

Compared structures

4FDL · Crystal structure of Caspase-7 · the same entry in another collection · chain A against A, TM-score 1.00
P55210 · AlphaFold monomer V2.0 prediction for caspase-7 (P55210) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P55210
Elsewhere: RCSB PDB 4FDL · PDBe 4FDL · UniProt P55210

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