MolNFT v1 · #91443 · protein
Crystal structure of an archaeal mcm filament
4FDG · Minichromosome maintenance protein mcm: “Crystal structure of an archaeal mcm filament”. X-ray diffraction, 1 ligand (ZN), 20 pockets (best druggability 0.82). MolNFT v1 #91443 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 4FDG
- Type
- protein
- Length
- 2,960 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Minichromosome maintenance protein mcm
- EC
- 3.6.4.12
- UniProt
- Q9UXG1
- Ligands
- ZN
- Pockets
- 20 · best druggability 0.82
Structure
x-ray diffraction · 1 distinct chain · 28% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B, A, C, D, E | Minichromosome maintenance protein mcm (EC 3.6.4.12) | protein | 592 | 28% helix, 19% strand | Q9UXG1 |
Ligands and binding sites
- ZN · Zinc ion · metal · 5 copies · chains B, A, C, D, E
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1045 | 0.82 | 0.83 | 89 | empty |
| 2 | 1060 | 0.82 | 0.83 | 95 | empty |
| 3 | 1180 | 0.82 | 0.83 | 104 | empty |
| 4 | 1124 | 0.82 | 0.83 | 101 | empty |
| 5 | 621 | 0.78 | 0.84 | 63 | empty |
Interfaces
4 interfaces between chains.
- A–D · 1855 Ų buried · 12 hydrogen bonds · protein-protein
- B–A · 1827 Ų buried · 12 hydrogen bonds · protein-protein
- B–C · 1817 Ų buried · 20 hydrogen bonds · protein-protein
- C–E · 1783 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UXG1
- Elsewhere: RCSB PDB 4FDG · PDBe 4FDG · UniProt Q9UXG1
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