MolNFT v1 · #91296 · protein

BRR2 helicase region S1087L

4F92 · U5 small nuclear ribonucleoprotein 200 kda helicase: “BRR2 helicase region S1087L”. X-ray diffraction, 1 ligand (SAN), 20 pockets (best druggability 0.85). MolNFT v1 #91296 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 4F92
Type: protein
Length: 1,723 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: U5 small nuclear ribonucleoprotein 200 kda helicase
EC: 3.6.4.13
UniProt: O75643
Ligands: SAN
Pockets: 20 · best druggability 0.85

Structure

x-ray diffraction · 1 distinct chain · 42% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	U5 small nuclear ribonucleoprotein 200 kda helicase (EC 3.6.4.13)	protein	1723	42% helix, 17% strand	O75643

Ligands and binding sites

SAN · Sulfanilamide · ligand · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	724	0.85	0.88	102	SAN
2	83	0.75	0.98	21	empty
3	738	0.74	0.80	50	empty
4	403	0.74	0.84	47	empty
5	96	0.73	0.95	19	empty

Compared structures

4F92 · Brr2 Helicase Region S1087L · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O75643
Elsewhere: RCSB PDB 4F92 · PDBe 4F92 · UniProt O75643

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