MolNFT v1 · #91001 · protein
Crystal structure of apo trka
4F0I · High affinity nerve growth factor receptor: “Crystal structure of apo trka”. X-ray diffraction, 6 pockets (best druggability 0.78). MolNFT v1 #91001 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4F0I
- Type
- protein
- Length
- 578 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- High affinity nerve growth factor receptor
- EC
- 2.7.10.1
- UniProt
- P04629
- Pockets
- 6 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 41% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | High affinity nerve growth factor receptor (EC 2.7.10.1) | protein | 284 | 41% helix, 17% strand | P04629 |
| B | High affinity nerve growth factor receptor (EC 2.7.10.1) | protein | 294 | 40% helix, 17% strand | P04629 |
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1191 | 0.78 | 0.79 | 98 | empty |
| 2 | 197 | 0.60 | 0.82 | 24 | empty |
| 3 | 182 | 0.57 | 0.80 | 24 | empty |
| 4 | 163 | 0.50 | 0.78 | 18 | empty |
| 5 | 97 | 0.36 | 0.74 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 604 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04629
- Elsewhere: RCSB PDB 4F0I · PDBe 4F0I · UniProt P04629
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