Crystal structure of the ut-B urea transporter from bos taurus bound to selenourea

Structure

x-ray diffraction · 2 distinct chains · 69% helix, 1% strand (DSSP).

Ligands and binding sites

• SEY · selenourea · ligand · 6 copies · chains A, B, C
• SPL · Octanoic acid (2-hydroxy-1-hydroxymethyl-heptadec-3-enyl)-amide · ligand · 3 copies · chains A, C, B
• BGC · beta-D-glucopyranose · sugar · 8 copies · chains A, B, C
• BOG · octyl beta-D-glucopyranoside · additive · 10 copies · chains A, B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

11 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.

Interfaces

3 interfaces between chains.

• B–C · 1224 Ų buried · 11 hydrogen bonds · protein-protein
• A–C · 1209 Ų buried · 11 hydrogen bonds · protein-protein
• A–B · 1202 Ų buried · 12 hydrogen bonds · protein-protein

Compared structures

• 4EZD · Crystal Structure of the UT-B Urea Transporter from Bos Taurus Bound to Selenourea · the same entry in another collection · chain A against A, TM-score 1.00
• Q5QF96 · AlphaFold monomer V2.0 prediction for urea transporter 1 (Q5QF96) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q5QF96
• Elsewhere: RCSB PDB 4EZD · PDBe 4EZD · UniProt Q5QF96