MolNFT v1 · #90951 · protein
CDK2 in complex with nsc 134199
4EZ3 · Cyclin-dependent kinase 2: “CDK2 in complex with nsc 134199”. X-ray diffraction, 1 ligand (0S0), 2 pockets (best druggability 0.75). MolNFT v1 #90951 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4EZ3
- Type
- protein
- Length
- 294 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cyclin-dependent kinase 2
- EC
- 2.7.11.22
- UniProt
- P24941
- Ligands
- 0S0
- Pockets
- 2 · best druggability 0.75
Structure
x-ray diffraction · 1 distinct chain · 34% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cyclin-dependent kinase 2 (EC 2.7.11.22) | protein | 294 | 34% helix, 15% strand | P24941 |
Ligands and binding sites
- 0S0 · 4-[(E)-(6-hydroxy-2-oxo-1,2-dihydropyridin-3-yl)diazenyl]benzenesulfonamide · ligand · chains A
- EDO · 1,2-ethanediol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 505 | 0.75 | 0.83 | 58 | 0S0 |
| 2 | 127 | 0.69 | 0.90 | 32 | EDO |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P24941
- Elsewhere: RCSB PDB 4EZ3 · PDBe 4EZ3 · UniProt P24941
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