MolNFT v1 · #90939 · protein

Human insulin

4EYP · Insulin a chain: “Human insulin”. X-ray diffraction, 2 ligands (ZN, CL). MolNFT v1 #90939 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4EYP
Type: protein
Length: 102 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Insulin a chain; Insulin B chain
UniProt: P01308
Ligands: ZN, CL

Structure

x-ray diffraction · 2 distinct chains · 57% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C	Insulin a chain	protein	21	67% helix, 14% strand	P01308
B, D	Insulin B chain	protein	30	50% helix, 17% strand	P01308

Ligands and binding sites

ZN · Zinc ion · metal · 2 copies · chains B, D
CL · Chloride ion · ion · 2 copies · chains B, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

5 interfaces between chains.

A–B · 910 Å² buried · 12 hydrogen bonds · protein-protein
C–D · 899 Å² buried · 13 hydrogen bonds · protein-protein
B–D · 639 Å² buried · 7 hydrogen bonds · protein-protein
B–C · 50 Å² buried · 1 hydrogen bond · protein-protein
A–D · 31 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

4EYP · Human Insulin · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01308
Elsewhere: RCSB PDB 4EYP · PDBe 4EYP · UniProt P01308

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