MolNFT v1 · #90926 · protein
Crystal structure of the cathelin-like domain of human cathelicidin ll-37 (hcld)
4EYC · Cathelicidin antimicrobial peptide: “Crystal structure of the cathelin-like domain of human cathelicidin ll-37 (hcld)”. X-ray diffraction, 2 pockets (best druggability 0.46). MolNFT v1 #90926 on GenesisL1: 3D structure, binding…
- PDB
- 4EYC
- Type
- protein
- Length
- 202 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cathelicidin antimicrobial peptide
- UniProt
- P49913
- Pockets
- 2 · best druggability 0.46
Structure
x-ray diffraction · 2 distinct chains · 18% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cathelicidin antimicrobial peptide | protein | 103 | 17% helix, 36% strand | P49913 |
| B | Cathelicidin antimicrobial peptide | protein | 99 | 18% helix, 35% strand | P49913 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 115 | 0.46 | 0.79 | 23 | empty |
| 2 | 77 | 0.36 | 0.77 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 720 Ų buried · 28 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 4EYC · Crystal structure of the cathelin-like domain of human cathelicidin LL-37 (hCLD) · the same entry in another collection · chain A against A, TM-score 1.00
- P49913 · AlphaFold monomer V2.0 prediction for cathelicidin antimicrobial peptide (P49913) · a predicted model of the same protein · chain B against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P49913
- Elsewhere: RCSB PDB 4EYC · PDBe 4EYC · UniProt P49913
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