MolNFT v1 · #90908 · protein
Structure of polymerase-interacting domain of human REV1 in complex with translesional synthesis polymerase zeta
4EXT · DNA repair protein REV1: “Structure of polymerase-interacting domain of human REV1 in complex with translesional synthesis polymerase…”. X-ray diffraction, 2 pockets (best druggability 0.43). MolNFT v1 #90908 on GenesisL1: 3D…
- PDB
- 4EXT
- Type
- protein
- Length
- 317 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA repair protein REV1; Peptide from DNA polymerase zeta catalytic subunit; Mitotic…
- EC
- 2.7.7.-
- UniProt
- Q9UBZ9, O60673, Q9UI95
- Pockets
- 2 · best druggability 0.43
Structure
x-ray diffraction · 3 distinct chains · 45% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA repair protein REV1 (EC 2.7.7.-) | protein | 96 | 70% helix, 4% strand | Q9UBZ9 |
| B | Peptide from DNA polymerase zeta catalytic subunit | protein | 23 | 17% helix, 17% strand | O60673 |
| C | Mitotic spindle assembly checkpoint protein MAD2B | protein | 198 | 36% helix, 30% strand | Q9UI95 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 152 | 0.43 | 0.75 | 20 | empty |
| 2 | 59 | 0.35 | 0.78 | 15 | empty |
Interfaces
2 interfaces between chains.
- B–C · 1207 Ų buried · 15 hydrogen bonds · protein-protein
- A–C · 701 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
- 4EXT · Structure of polymerase-interacting domain of human Rev1 in complex with translesional… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UBZ9 · AlphaFold monomer V2.0 prediction for DNA repair protein REV1 (Q9UBZ9) · a predicted model of the same protein · chain A against A, TM-score 0.97
- Q9UI95 · AlphaFold monomer V2.0 prediction for mitotic spindle assembly checkpoint protein MAD2B… · a predicted model of the same protein · chain C against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UBZ9
- Every structure of UniProt O60673
- Every structure of UniProt Q9UI95
- Elsewhere: RCSB PDB 4EXT · PDBe 4EXT · UniProt Q9UBZ9 · UniProt O60673 · UniProt Q9UI95
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