MolNFT v1 · #90831 · protein

Crystal structure of mouse catenin beta-59 in 2.4M urea.

4EV8 · Catenin beta-1: “Crystal structure of mouse catenin beta-59 in 2.4M urea.”. X-ray diffraction, 1 ligand (URE), 2 pockets (best druggability 0.46). MolNFT v1 #90831 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4EV8
Type: protein
Length: 492 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Catenin beta-1
UniProt: Q02248
Ligands: URE
Pockets: 2 · best druggability 0.46

Structure

x-ray diffraction · 1 distinct chain · 73% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Catenin beta-1	protein	492	73% helix, 0% strand	Q02248

Ligands and binding sites

URE · Urea · ligand · 18 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	183	0.46	0.75	25	URE
2	56	0.35	0.79	19	empty

Compared structures

4EV8 · Crystal structure of mouse catenin beta-59 in 2.4M urea. · the same entry in another collection · chain A against A, TM-score 1.00
Q02248 · AlphaFold monomer V2.0 prediction for catenin beta-1 (Q02248) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q02248
Elsewhere: RCSB PDB 4EV8 · PDBe 4EV8 · UniProt Q02248

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