MolNFT v1 · #90787 · protein

Crystal structure of mouse ryanodine receptor 2 (2699-2904)

4ETV: “Crystal structure of mouse ryanodine receptor 2 (2699-2904)”. X-ray diffraction, 1 ligand (CL), 4 pockets (best druggability 0.65). MolNFT v1 #90787 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4ETV
Type: protein
Length: 326 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ryanodine receptor 2
UniProt: E9Q401
Ligands: CL
Pockets: 4 · best druggability 0.65

Structure

x-ray diffraction · 2 distinct chains · 59% helix, 6% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ryanodine receptor 2	protein	191	57% helix, 6% strand	E9Q401
B	Ryanodine receptor 2	protein	135	62% helix, 6% strand	E9Q401

Ligands and binding sites

CL · Chloride ion · ion · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	672	0.65	0.74	57	empty
2	85	0.36	0.75	18	empty
3	75	0.32	0.74	17	empty
4	56	0.29	0.74	10	empty

Interfaces

1 interface between chains.

A–B · 685 Å² buried · 8 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 13 modified (engineered).

Compared structures

4ETV · Crystal structure of mouse ryanodine receptor 2 (2699-2904) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt E9Q401
Elsewhere: RCSB PDB 4ETV · PDBe 4ETV · UniProt E9Q401

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