MolNFT v1 · #9074 · protein
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
1HKA: “6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase”. X-ray diffraction, 2 pockets (best druggability 0.45). MolNFT v1 #9074 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1HKA
- Type
- protein
- Length
- 158 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
- EC
- 2.7.6.3
- UniProt
- P26281
- Pockets
- 2 · best druggability 0.45
Structure
x-ray diffraction · 1 distinct chain · 32% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (EC 2.7.6.3) | protein | 158 | 32% helix, 27% strand | P26281 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 99 | 0.45 | 0.79 | 18 | empty |
| 2 | 68 | 0.31 | 0.74 | 13 | empty |
Compared structures
- 1HKA · 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase · the same entry in another collection · chain A against A, TM-score 1.00
- P26281 · AlphaFold monomer V2.0 prediction for 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine… · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P26281
- Elsewhere: RCSB PDB 1HKA · PDBe 1HKA · UniProt P26281
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