MolNFT v1 · #90647 · protein

The crystal structure of pesticin-T4 lysozyme hybrid stabilized by engineered disulfide bonds

4EPI · Pesticin, lysozyme chimera: “The crystal structure of pesticin-T4 lysozyme hybrid stabilized by engineered disulfide bonds”. X-ray diffraction, 2 ligands (NA, SO4), 3 pockets (best druggability 0.53). MolNFT v1 #90647 on GenesisL1…

PDB: 4EPI
Type: protein
Length: 329 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Pesticin, lysozyme chimera
EC: 3.2.1.17
UniProt: Q57159, P00720
Ligands: NA, SO4
Pockets: 3 · best druggability 0.53

Structure

x-ray diffraction · 1 distinct chain · 42% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Pesticin, lysozyme chimera (EC 3.2.1.17)	protein	329	42% helix, 19% strand	Q57159, P00720

Ligands and binding sites

NA · Sodium ion · metal · 4 copies · chains A
SO4 · Sulfate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	226	0.53	0.76	30	empty
2	83	0.33	0.75	20	empty
3	79	0.30	0.72	16	empty

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

4EPI · The crystal structure of pesticin-T4 lysozyme hybrid stabilized by engineered disulfide… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q57159
Every structure of UniProt P00720
Elsewhere: RCSB PDB 4EPI · PDBe 4EPI · UniProt Q57159 · UniProt P00720

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