MolNFT v1 · #90603 · protein
Crystal structure of the tir domain of human myeloid differentiation primary response protein 88.
4EO7 · Myeloid differentiation primary response protein MYD88: “Crystal structure of the tir domain of human myeloid differentiation primary response protein 88.”. X-ray diffraction, 1 ligand (MG), 2 pockets (best druggability 0.35).…
- PDB
- 4EO7
- Type
- protein
- Length
- 144 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Myeloid differentiation primary response protein MYD88
- UniProt
- Q99836
- Ligands
- MG
- Pockets
- 2 · best druggability 0.35
Structure
x-ray diffraction · 1 distinct chain · 42% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Myeloid differentiation primary response protein MYD88 | protein | 144 | 42% helix, 18% strand | Q99836 |
Ligands and binding sites
- MG · Magnesium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 56 | 0.35 | 0.78 | 14 | empty |
| 2 | 62 | 0.29 | 0.74 | 13 | empty |
Modifications
Observed in the structure: 1 modified (oxidation).
Compared structures
- 4EO7 · Crystal structure of the TIR domain of human myeloid differentiation primary response… · the same entry in another collection · chain A against A, TM-score 1.00
- Q99836 · AlphaFold monomer V2.0 prediction for myeloid differentiation primary response protein… · a predicted model of the same protein · chain A against A, TM-score 0.84
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q99836
- Elsewhere: RCSB PDB 4EO7 · PDBe 4EO7 · UniProt Q99836
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