Research workbench
Crystal structure of the tir domain of human myeloid differentiation primary response protein 88.
Analyse Crystal structure of the tir domain of human myeloid differentiation primary… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4EO7
- Type
- protein
- Length
- 144 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Myeloid differentiation primary response protein MYD88
- UniProt
- Q99836
- Ligands
- MG
- Pockets
- 2 · best druggability 0.35
Structure
x-ray diffraction · 1 distinct chain · 42% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Myeloid differentiation primary response protein MYD88 | protein | 144 | 42% helix, 18% strand | Q99836 |
Ligands and binding sites
- MG · Magnesium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 56 | 0.35 | 0.78 | 14 | empty |
| 2 | 62 | 0.29 | 0.74 | 13 | empty |
Modifications
Observed in the structure: 1 modified (oxidation).
Compared structures
- 4EO7 · Crystal structure of the TIR domain of human myeloid differentiation primary response… · the same entry in another collection · chain A against A, TM-score 1.00
- Q99836 · AlphaFold monomer V2.0 prediction for myeloid differentiation primary response protein… · a predicted model of the same protein · chain A against A, TM-score 0.84
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q99836
- Elsewhere: RCSB PDB 4EO7 · PDBe 4EO7 · UniProt Q99836
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