MolNFT v1 · #90593 · protein

Crystal structure of pim-1 kinase in complex with inhibitor (2E,5Z)-2- (2-chlorophenylimino)-5-(4-hydroxy-3-NITROBENZYLIDENE)THIAZOLIDIN-4- one

4ENX · SERINE/THREONINE-protein kinase pim-1: “Crystal structure of pim-1 kinase in complex with inhibitor (2E,5Z)-2…”. X-ray diffraction, 2 ligands (Z20, PO4), 2 pockets (best druggability 0.66). MolNFT v1 #90593 on GenesisL1: 3D…

PDB: 4ENX
Type: protein
Length: 266 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SERINE/THREONINE-protein kinase pim-1
EC: 2.7.11.1
UniProt: P11309
Ligands: Z20, PO4
Pockets: 2 · best druggability 0.66

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	SERINE/THREONINE-protein kinase pim-1 (EC 2.7.11.1)	protein	266	40% helix, 23% strand	P11309

Ligands and binding sites

Z20 · (2Z,5Z)-2-[(2-chlorophenyl)imino]-5-(4-hydroxy-3-nitrobenzylidene)-1,3-thiazolidin-4-one · ligand · chains A
PO4 · Phosphate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	278	0.66	0.82	33	Z20
2	91	0.54	0.84	21	empty

Compared structures

4ENX · Crystal Structure of Pim-1 Kinase in complex with inhibitor… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P11309
Elsewhere: RCSB PDB 4ENX · PDBe 4ENX · UniProt P11309

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.