MolNFT v1 · #90506 · protein
Crystal structure of an activated variant of small heat shock protein HSP16.5
4ELD: “Crystal structure of an activated variant of small heat shock protein HSP16.5”. X-ray diffraction, 2 pockets (best druggability 0.55). MolNFT v1 #90506 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4ELD
- Type
- protein
- Length
- 231 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Small heat shock protein HSP16.5
- UniProt
- Q57733
- Pockets
- 2 · best druggability 0.55
Structure
x-ray diffraction · 2 distinct chains · 8% helix, 48% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Small heat shock protein HSP16.5 | protein | 117 | 8% helix, 48% strand | Q57733 |
| B | Small heat shock protein HSP16.5 | protein | 114 | 8% helix, 49% strand | Q57733 |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 217 | 0.55 | 0.78 | 30 | empty |
| 2 | 191 | 0.52 | 0.78 | 31 | empty |
Interfaces
1 interface between chains.
- A–B · 1869 Ų buried · 32 hydrogen bonds · protein-protein
Compared structures
- 4ELD · Crystal Structure of an Activated Variant of Small Heat Shock Protein Hsp16.5 · the same entry in another collection · chain A against A, TM-score 1.00
- Q57733 · AlphaFold monomer V2.0 prediction for small heat shock protein HSP16.5 (Q57733) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q57733
- Elsewhere: RCSB PDB 4ELD · PDBe 4ELD · UniProt Q57733
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