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Crystal structure of an activated variant of small heat shock protein HSP16.5

Analyse Crystal structure of an activated variant of small heat shock protein HSP16.5 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4ELD
Type: protein
Length: 231 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Small heat shock protein HSP16.5
UniProt: Q57733
Pockets: 2 · best druggability 0.55

Structure

x-ray diffraction · 2 distinct chains · 8% helix, 48% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Small heat shock protein HSP16.5	protein	117	8% helix, 48% strand	Q57733
B	Small heat shock protein HSP16.5	protein	114	8% helix, 49% strand	Q57733

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	217	0.55	0.78	30	empty
2	191	0.52	0.78	31	empty

Interfaces

1 interface between chains.

A–B · 1869 Å² buried · 32 hydrogen bonds · protein-protein

Compared structures

4ELD · Crystal Structure of an Activated Variant of Small Heat Shock Protein Hsp16.5 · the same entry in another collection · chain A against A, TM-score 1.00
Q57733 · AlphaFold monomer V2.0 prediction for small heat shock protein HSP16.5 (Q57733) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q57733
Elsewhere: RCSB PDB 4ELD · PDBe 4ELD · UniProt Q57733

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