MolNFT v1 · #90431 · protein
Structure of the delta opioid receptor bound to naltrindole
4EJ4 · Delta-type opioid receptor, lysozyme chimera: “Structure of the delta opioid receptor bound to naltrindole”. X-ray diffraction, 1 ligand (EJ4), 4 pockets (best druggability 0.73). MolNFT v1 #90431 on GenesisL1: 3D structure, binding…
- PDB
- 4EJ4
- Type
- protein
- Length
- 442 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Delta-type opioid receptor, lysozyme chimera
- EC
- 3.2.1.17
- UniProt
- P32300, P00720
- Ligands
- EJ4
- Pockets
- 4 · best druggability 0.73
Structure
x-ray diffraction · 1 distinct chain · 74% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Delta-type opioid receptor, lysozyme chimera (EC 3.2.1.17) | protein | 442 | 74% helix, 7% strand | P32300, P00720 |
Ligands and binding sites
- EJ4 · (4bS,8R,8aS,14bR)-7-(cyclopropylmethyl)-5,6,7,8,14,14b-hexahydro-4,8-methano[1]benzofuro[2,3-a]pyrido[4,3-b]carbazole-1,8a(9H)-diol · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 664 | 0.73 | 0.79 | 51 | EJ4 |
| 2 | 115 | 0.38 | 0.74 | 19 | empty |
| 3 | 89 | 0.35 | 0.74 | 15 | empty |
| 4 | 69 | 0.32 | 0.74 | 18 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P32300
- Every structure of UniProt P00720
- Elsewhere: RCSB PDB 4EJ4 · PDBe 4EJ4 · UniProt P32300 · UniProt P00720
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.