MolNFT v1 · #90053 · protein

Crystal structure of receiver domain of putative narl family response regulator SPR1814 from streptococcus pneumoniae

4E7O: “Crystal structure of receiver domain of putative narl family response regulator SPR1814 from streptococcus…”. X-ray diffraction, 1 ligand (MG), 3 pockets (best druggability 0.47). MolNFT v1 #90053 on GenesisL1: 3D structure, binding…

PDB: 4E7O
Type: protein
Length: 261 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Response regulator
UniProt: Q8DNC2
Ligands: MG
Pockets: 3 · best druggability 0.47

Structure

x-ray diffraction · 2 distinct chains · 40% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Response regulator	protein	130	40% helix, 23% strand	Q8DNC2
B	Response regulator	protein	131	40% helix, 23% strand	Q8DNC2

Ligands and binding sites

MG · Magnesium ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	74	0.47	0.82	19	empty
2	130	0.44	0.76	23	empty
3	54	0.34	0.78	16	empty

Interfaces

1 interface between chains.

A–B · 360 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

4E7O · Crystal structure of receiver domain of putative NarL family response regulator spr1814… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8DNC2
Elsewhere: RCSB PDB 4E7O · PDBe 4E7O · UniProt Q8DNC2

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