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Crystal structure of receiver domain of putative narl family response regulator SPR1814 from streptococcus pneumoniae

Analyse Crystal structure of receiver domain of putative narl family response regulator… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4E7O
Type: protein
Length: 261 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Response regulator
UniProt: Q8DNC2
Ligands: MG
Pockets: 3 · best druggability 0.47

Structure

x-ray diffraction · 2 distinct chains · 40% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Response regulator	protein	130	40% helix, 23% strand	Q8DNC2
B	Response regulator	protein	131	40% helix, 23% strand	Q8DNC2

Ligands and binding sites

MG · Magnesium ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	74	0.47	0.82	19	empty
2	130	0.44	0.76	23	empty
3	54	0.34	0.78	16	empty

Interfaces

1 interface between chains.

A–B · 360 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

4E7O · Crystal structure of receiver domain of putative NarL family response regulator spr1814… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8DNC2
Elsewhere: RCSB PDB 4E7O · PDBe 4E7O · UniProt Q8DNC2

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