MolNFT v1 · #90006 · protein
The structure of the polo-box domain (pbd) of polo-like kinase 1 (PLK1) in complex with hydrocinnamoyl-derivatized plhspta peptide
4E67 · SERINE/THREONINE-protein kinase PLK1: “The structure of the polo-box domain (pbd) of polo-like kinase 1 (PLK1) in complex with…”. X-ray diffraction, 2 ligands (HCI, NH2). MolNFT v1 #90006 on GenesisL1: 3D structure, binding sites…
- PDB
- 4E67
- Type
- protein
- Length
- 219 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SERINE/THREONINE-protein kinase PLK1; Hydrocinnamoyl-derivatized plhspta peptide
- EC
- 2.7.11.21
- UniProt
- P53350
- Ligands
- HCI, NH2
Structure
x-ray diffraction · 2 distinct chains · 31% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SERINE/THREONINE-protein kinase PLK1 (EC 2.7.11.21) | protein | 213 | 32% helix, 31% strand | P53350 |
| B | Hydrocinnamoyl-derivatized plhspta peptide | protein | 6 | 0% helix, 33% strand | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
1 interface between chains.
- A–B · 500 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 covalent, 1 modified (covalent ligand, phosphorylation).
Compared structures
- 4E67 · The structure of the polo-box domain (PBD) of polo-like kinase 1 (Plk1) in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P53350
- Elsewhere: RCSB PDB 4E67 · PDBe 4E67 · UniProt P53350
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