UniProt P53350
Serine/threonine-protein kinase PLK1 (P53350)
Serine/threonine-protein kinase PLK1 (UniProt P53350), EC 2.7.11.21: 130 experimental structures on GenesisL1, 11 ligands bound, 20 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P53350
- Protein
- Serine/threonine-protein kinase PLK1
- EC
- 2.7.11.21
- Experimental structures
- 130
- Predicted models
- 0
- Ligands
- 11
- Pockets
- 20 · 3 records with a druggable one
Structures
130 records of P53350 in the MolNFT archive: 130 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1Q4K | The polo-box domain of Plk1 in complex with a phospho-peptide | x-ray diffraction | B, A, C | — | — |
| 1Q4K | The polo-box domain of PLK1 in complex with a phospho- peptide | x-ray diffraction | B, A, C | — | — |
| 1Q4O | The structure of the polo box domain of human Plk1 | x-ray diffraction | A, B | — | — |
| 1Q4O | The structure of the polo box domain of human PLK1 | x-ray diffraction | A, B | — | — |
| 1UMW | Structure of a human Plk1 Polo-box domain/phosphopeptide complex | x-ray diffraction | A, B | — | — |
| 1UMW | Structure of a human PLK1 polo-box DOMAIN/PHOSPHOPEPTIDE complex | x-ray diffraction | A, B | — | — |
| 2OGQ | Molecular and structural basis of Plk1 substrate recognition: Implications in centrosomal… | x-ray diffraction | A | — | — |
| 2OGQ | Molecular and structural basis of PLK1 substrate recognition: implications in centrosomal… | x-ray diffraction | A | — | — |
| 2OJX | Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications in… | x-ray diffraction | A | — | — |
| 2OJX | Molecular and structural basis of polo-like kinase 1 substrate recognition: implications in… | x-ray diffraction | A | — | — |
| 2OU7 | Structure of the Catalytic Domain of Human Polo-like Kinase 1 | x-ray diffraction | A | — | — |
| 2OU7 | Structure of the catalytic domain of human polo-like kinase 1 | x-ray diffraction | A | — | — |
| 2OWB | Structure of the Catalytic Domain of Human Polo-like Kinase 1 | x-ray diffraction | A | — | — |
| 2OWB | Structure of the catalytic domain of human polo-like kinase 1 | x-ray diffraction | A | — | — |
| 2RKU | Structure of PLK1 in complex with BI2536 | x-ray diffraction | A | — | — |
| 2RKU | Structure of PLK1 in complex with BI2536 | x-ray diffraction | A | — | — |
| 2V5Q | Crystal structure of wild-type plk-1 kinase domain in complex with a selective darpin | x-ray diffraction | A, B | — | — |
| 2V5Q | Crystal structure of wild-type plk-1 kinase domain in complex with a selective darpin | x-ray diffraction | A, B | — | — |
| 2YAC | Crystal structure of Polo-like kinase 1 in complex with NMS-P937 | x-ray diffraction | A | — | — |
| 2YAC | Crystal structure of polo-like kinase 1 in complex with nms-P937 | x-ray diffraction | A | — | — |
| 3BZI | Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications in… | x-ray diffraction | A | — | — |
| 3BZI | Molecular and structural basis of polo-like kinase 1 substrate recognition: implications in… | x-ray diffraction | A | — | — |
| 3C5L | Polo-like kinase 1 Polo box domain in complex with PPHSpT peptide | x-ray diffraction | A | — | — |
| 3C5L | Polo-like kinase 1 polo box domain in complex with pphspt peptide | x-ray diffraction | A | — | — |
| 3FC2 | PLK1 in complex with BI6727 | x-ray diffraction | A | — | — |
| 3FC2 | PLK1 in complex with BI6727 | x-ray diffraction | A | — | — |
| 3FVH | Polo-like kinase 1 Polo box domain in complex with Ac-LHSpTA-NH2 peptide | x-ray diffraction | A | — | — |
| 3FVH | Polo-like kinase 1 polo box domain in complex with ac-lhspta-NH2 peptide | x-ray diffraction | A | — | — |
| 3HIH | Structure of human Plk1-PBD with glycerol and sulfate in the phophopeptide binding site | x-ray diffraction | A, B | — | — |
| 3HIH | Structure of human PLK1-pbd with glycerol and sulfate in the phophopeptide binding site | x-ray diffraction | A, B | — | — |
| 3HIK | Structure of human Plk1-PBD in complex with PLHSpT | x-ray diffraction | A | — | — |
| 3HIK | Structure of human PLK1-pbd in complex with plhspt | x-ray diffraction | A | — | — |
| 3KB7 | Crystal structure of Polo-like kinase 1 in complex with a pyrazoloquinazoline inhibitor | x-ray diffraction | A | — | — |
| 3KB7 | Crystal structure of polo-like kinase 1 in complex with a pyrazoloquinazoline inhibitor | x-ray diffraction | A | — | — |
| 3P2W | Unliganded form of Polo-like kinase I Polo-box domain | x-ray diffraction | A | — | — |
| 3P2W | Unliganded form of polo-like kinase I polo-box domain | x-ray diffraction | A | — | — |
| 3P2Z | Polo-like kinase I Polo-box domain in complex with PLHSpTA phosphopeptide from PBIP1 | x-ray diffraction | A | — | — |
| 3P2Z | Polo-like kinase I polo-box domain in complex with plhspta phosphopeptide from PBIP1 | x-ray diffraction | A | — | — |
| 3P34 | Polo-like kinase I Polo-box domain in complex with MQSpTPL phosphopeptide | x-ray diffraction | A | — | — |
| 3P34 | Polo-like kinase I polo-box domain in complex with mqsptpl phosphopeptide | x-ray diffraction | A | — | — |
| 3P35 | Polo-like kinase I Polo-box domain in complex with MQSpSPL phosphopeptide | x-ray diffraction | A, B, C | — | — |
| 3P35 | Polo-like kinase I polo-box domain in complex with mqspspl phosphopeptide | x-ray diffraction | A, B, C | — | — |
| 3P36 | Polo-like kinase I Polo-box domain in complex with DPPLHSpTA phosphopeptide from PBIP1 | x-ray diffraction | A | — | — |
| 3P36 | Polo-like kinase I polo-box domain in complex with dpplhspta phosphopeptide from PBIP1 | x-ray diffraction | A | — | — |
| 3P37 | Polo-like kinase I Polo-box domain in complex with FDPPLHSpTA phosphopeptide from PBIP1 | x-ray diffraction | A, B, C | — | — |
| 3P37 | Polo-like kinase I polo-box domain in complex with fdpplhspta phosphopeptide from PBIP1 | x-ray diffraction | A, B, C | — | — |
| 3Q1I | Polo-like kinase I Polo-box domain in complex with FMPPPMSpSM phosphopeptide from TCERG1 | x-ray diffraction | A | — | — |
| 3Q1I | Polo-like kinase I polo-box domain in complex with fmpppmspsm phosphopeptide from TCERG1 | x-ray diffraction | A | — | — |
| 3RQ7 | Polo-like kinase 1 Polo box domain in complex with a C6H5(CH2)8-derivatized peptide inhibitor | x-ray diffraction | A | — | — |
| 3RQ7 | Polo-like kinase 1 polo box domain in complex with a C6H5(CH2)8- derivatized peptide inhibitor | x-ray diffraction | A | — | — |
| 3THB | Structure of PLK1 kinase domain in complex with a benzolactam-derived inhibitor | x-ray diffraction | A | — | — |
| 3THB | Structure of PLK1 kinase domain in complex with a benzolactam-derived inhibitor | x-ray diffraction | A | — | — |
| 4A4L | Crystal structure of polo-like kinase 1 in complex with a 5-(2-amino- pyrimidin-4-yl)-1H-pyrrole… | x-ray diffraction | A | — | — |
| 4A4L | Crystal structure of polo-like kinase 1 in complex with a 5-(2-amino- pyrimidin-4-yl)-1H-pyrrole… | x-ray diffraction | A | — | — |
| 4A4O | Crystal structure of polo-like kinase 1 in complex with a 2-(2-amino… | x-ray diffraction | A | — | — |
| 4A4O | Crystal structure of polo-like kinase 1 in complex with a 2-(2-amino… | x-ray diffraction | A | — | — |
| 4DFW | Oxime-based Post Solid-phase Peptide Diversification: Identification of High Affinity Polo-like… | x-ray diffraction | A | — | — |
| 4DFW | Oxime-based post solid-phase peptide diversification: identification of high affinity polo-like… | x-ray diffraction | A | — | — |
| 4E67 | The structure of the polo-box domain (PBD) of polo-like kinase 1 (Plk1) in complex with… | x-ray diffraction | A | — | — |
| 4E67 | The structure of the polo-box domain (pbd) of polo-like kinase 1 (PLK1) in complex with… | x-ray diffraction | A | — | — |
70 records more on the page itself.
Ligands
- 8Z5 · Alpha-Bromo-3-Iodotoluene · in 4 records
- ZN · Zinc ion · in 3 records
- AML · Amylamine · in 2 records
- Z24 · (3~{R},5~{R})-1-[2,4-bis(fluoranyl)phenyl]-5-oxidanyl-pyrrolidine-3-carboxylic acid · in 2 records
- ZOY · N-[(4S)-4,5-diamino-5-oxopentyl]-10-phenyldecanamide · in 2 records
- 79C · 4-[(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-yl) amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide · in 1 record
- 79D · 4-{[(6R)-7-cyano-5-cyclopentyl-6-ethyl-5,6-dihydroimidazo[1,5-f]pteridin-3-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide · in 1 record
- 8VB · 2-[[3-[[5-(3-iodanylphenyl)carbonylthiophen-2-yl]carbonylamino]phenyl]methyl]propanedioic acid · in 1 record
- 8X7 · 1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-(prop-2-en-1-yl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one · in 1 record
- ACE · Acetyl group · in 1 record
- ZO1 · 3-(trifluoromethyl)benzaldehyde · in 1 record
Elsewhere
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