MolNFT v1 · #89978 · protein

The W197A mutant of P38A MAP kinase

4E5A · Mitogen-activated protein kinase 14: “The W197A mutant of P38A MAP kinase”. X-ray diffraction, 3 pockets (best druggability 0.61). MolNFT v1 #89978 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4E5A
Type: protein
Length: 332 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mitogen-activated protein kinase 14
EC: 2.7.11.24
UniProt: Q16539
Pockets: 3 · best druggability 0.61

Structure

x-ray diffraction · 1 distinct chain · 37% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
X	Mitogen-activated protein kinase 14 (EC 2.7.11.24)	protein	332	37% helix, 16% strand	Q16539

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	362	0.61	0.77	39	empty
2	183	0.48	0.76	19	empty
3	92	0.39	0.77	19	empty

Compared structures

4E5A · The W197A mutant of p38a MAP kinase · the same entry in another collection · chain X against X, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q16539
Elsewhere: RCSB PDB 4E5A · PDBe 4E5A · UniProt Q16539

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